Étienne Audet-Walsh

• Centre de recherche du CHU de Québec - Université Laval
• Centre de recherche en reproduction, développement et santé intergénérationnelle
• Centre de recherche sur le cancer

Financements des 2 dernières années

• Akhil Shukla, Stage postdoctoral en médecine
• Camille Lafront, Stage postdoctoral en médecine
• Heitor Cappato Guerra Silva, Doctorat en médecine moléculaire
• Louis Olivier Francois Freville, Maîtrise en médecine moléculaire - avec mémoire
• Louis Olivier Francois Freville, Doctorat en médecine moléculaire
• Lucas Galey, Maîtrise en médecine moléculaire - avec mémoire
• Lucas Galey, Doctorat en médecine moléculaire
• Mame Sokhna Sylla, Doctorat en médecine moléculaire
• Maxime Labroy, Maîtrise en médecine moléculaire - avec mémoire
• Maxime Labroy, Doctorat en médecine moléculaire

Encadrements des 5 dernières années

• Alice Fradet, Doctorat en nutrition
• Aurélie Lacouture, Doctorat en médecine moléculaire
• Aurélie Lacouture, Maîtrise en médecine moléculaire - avec mémoire
• Camille Lafront, Doctorat en médecine moléculaire
• Cynthia Jobin, Maîtrise en médecine moléculaire - avec mémoire
• Dina Irsenco, Maîtrise en médecine moléculaire - avec mémoire
• Kevin Gonthier, Doctorat en médecine moléculaire
• Lucas Germain, Doctorat en médecine moléculaire
• Lucas Germain, Maîtrise en médecine moléculaire - avec mémoire
• Mame Sokhna Sylla, Maîtrise en médecine moléculaire - avec mémoire
• Marie-Kim St-Pierre, Doctorat en médecine moléculaire
• Raul Cotau, Maîtrise en médecine moléculaire - avec mémoire
• Virginie Paquette, Maîtrise en médecine moléculaire - avec mémoire

Travaux de recherche des 5 dernières années

Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cycles MOLECULAR METABOLISM, 2026. DOI 10.1016/J.MOLMET.2025.102316

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner SCIENTIFIC REPORTS, 2026. DOI 10.1038/S41598-026-37825-Z

ASCC3 promotes chemosensitivity in colorectal cancer cells SCIENTIFIC REPORTS, 2026. DOI 10.1038/S41598-026-43173-9

Lactose quantification in human breast milk by gas chromatography - mass spectrometry METHODSX, 2026. DOI 10.1016/J.MEX.2026.103945

The selective estrogen receptor modulator bazedoxifene affects the metabolism and functions of human neutrophils JOURNAL OF LEUKOCYTE BIOLOGY, 2026. DOI 10.1093/JLEUKO/QIAG007

Late gestational exposure to flutamide alters stromal composition and immune landscape in the rat mammary gland during pre-puberty, peri-puberty, and adulthood TOXICOLOGICAL SCIENCES, 2026. DOI 10.1093/TOXSCI/KFAG053

An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands TOXICOLOGICAL SCIENCES, 2026. DOI 10.1093/TOXSCI/KFAF157

Molecular and cellular consequences of anti-androgenic in utero exposure on postnatal mammary gland development in rats CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2026.

Variations in Human Milk Metabolites After Gestational Diabetes: Associations with Infant Growth Nutrients, 2025. Alice Fradet, Line Berthiaume, Laurie-Anne Laroche, Camille Dugas, Julie Perron, Alain Doyen, Étienne Audet-Walsh, Julie Robitaille. DOI 10.3390/nu17091466

Glioblastoma gene expression-based subtypes have defined metabolomic states bioRxiv, 2025. DOI 10.1101/2025.09.05.674480

Combining anti-metabolic treatments with the repurposing of eribulin for glioblastoma: a clinical opportunity? TRANSLATIONAL CANCER RESEARCH, 2025. DOI 10.21037/TCR-2025-1962

Feasibility and acceptability of a personalised primary prevention strategy for women and men at high risk of breast and prostate cancer: the 3PC study protocol for a pilot randomised controlled trial BMJ OPEN, 2025. DOI 10.1136/BMJOPEN-2024-085255

RNA-seq dataset of the estrogen-dependent regulation of the transcriptome in mouse mammary gland organoids DATA IN BRIEF, 2025. DOI 10.1016/J.DIB.2025.111984

The rat mammary gland undergoes dynamic transcriptomic and lipidomic modifications from pre-puberty to adulthood SCIENTIFIC REPORTS, 2025. DOI 10.1038/S41598-025-97532-Z

Effect of larval rearing temperature on steroidogenesis pathway development in winter flounder (Pseudopleuronectes americanus) early life history COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2025. DOI 10.1016/J.CBPA.2024.111770

Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency STAR PROTOCOLS, 2024. DOI 10.1016/J.XPRO.2024.103200

Sex differences in mitochondrial gene expression during viral myocarditis BIOLOGY OF SEX DIFFERENCES, 2024. DOI 10.1186/S13293-024-00678-0

PSA, an outdated biomarker for prostate cancer: In search of a more specific biomarker, citrate takes the spotlight JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2024. DOI 10.1016/J.JSBMB.2024.106588

Bulk mRNA-seq data from wild-type and prostate cancer-developing mice reveal a reprogramming of the estrogen and androgen responses after carcinogenesis DATA IN BRIEF, 2024. DOI 10.1016/J.DIB.2024.110870

The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression JOURNAL OF CLINICAL INVESTIGATION, 2024. DOI 10.1172/JCI170809

Bulk mRNA-sequencing data of the estrogen and androgen responses in the human prostate cancer cell line VCaP DATA IN BRIEF, 2024. DOI 10.1016/J.DIB.2024.111053

Rediscovering citrate as a biomarker for prostate cancer NATURE REVIEWS UROLOGY, 2024. DOI 10.1038/S41585-024-00899-3

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis SCIENCE ADVANCES, 2024. DOI 10.1126/SCIADV.ADK9681

Preclinical models of prostate cancer - modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo. Nature reviews. Urology, 2023. Germain L, Lafront C, Paquette V, Neveu B, Paquette JS, Pouliot F, Audet-Walsh É.

Preclinical models of prostate cancer - modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo NATURE REVIEWS UROLOGY, 2023. DOI 10.1038/S41585-023-00726-1

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer MOLECULAR ONCOLOGY, 2023. DOI 10.1002/1878-0261.13441

Role of Secreted Frizzled-Related Protein 1 in Early Breast Carcinogenesis and Breast Cancer Aggressiveness CANCERS, 2023. DOI 10.3390/CANCERS15082251

An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models CANCERS, 2023. DOI 10.3390/CANCERS15113033

Estrogens and endocrine-disrupting chemicals differentially impact the bioenergetic fluxes of mammary epithelial cells in two- and three-dimensional models ENVIRONMENT INTERNATIONAL, 2023. DOI 10.1016/J.ENVINT.2023.108132

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle in prostate cancer CANCER RESEARCH, 2023. DOI 10.1158/1538-7445.AM2023-3700

The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements METABOLITES, 2023. DOI 10.3390/METABO13111157

UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways CANCER LETTERS, 2023. DOI 10.1016/J.CANLET.2022.215994

UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways. Cancer letters, 2022. Lacombe L, Hovington H, Brisson H, Mehdi S, Beillevaire D, Émond JP, Wagner A, Villeneuve L, Simonyan D, Ouellet V, Barrès V, Latour M, Aprikian A, Lévesque E.

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation. NAR cancer, 2022. Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI.

Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency. Communications biology, 2022. Dufour CR, Xia H, B'chir W, Perry MC, Kuzmanov U, Gainullina A, Dejgaard K, Scholtes C, Ouellet C, Zuo D, Sanguin-Gendreau V, Guluzian C, Smith HW, Giguère V.

FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture. MethodsX, 2022. Frégeau-Proulx L, Lacouture A, Weidmann C, Jobin C, Audet-Walsh É.

Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1. Cancer letters, 2022. Laurin KM, Coutu-Beaudry K, Salazar A, Méribout N, Audet-Walsh É, Gravel SP.

Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion. Molecular metabolism, 2022. Frégeau-Proulx L, Lacouture A, Berthiaume L, Weidmann C, Harvey M, Gonthier K, Pelletier JF, Neveu B, Jobin C, Bastien D, Bergeron A, Fradet Y, Audet-Walsh É.

Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients. Oncogene, 2022. Bramhecha YM, Guérard KP, Audet-Walsh É, Rouzbeh S, Kassem O, Pernet E, Scarlata E, Hamel L, Brimo F, Divangahi M, Aprikian AG, Chevalier S, Lapointe J.

A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions. Frontiers in molecular biosciences, 2022. Loehr J, Kougnassoukou Tchara PE, Gonthier K, Noufi C, Linteau N, Audet-Walsh É, Lambert JP.

Impacts of endocrine-disrupting chemicals on prostate function and cancer ENVIRONMENTAL RESEARCH, 2022. DOI 10.1016/J.ENVRES.2021.112085

A FACS-free purification method to study estrogen signaling, organoid formation, and metabolic reprogramming in mammary epithelial cells CANCER RESEARCH, 2022. DOI 10.1158/1538-7445.SABCS21-P5-02-01

A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions FRONTIERS IN MOLECULAR BIOSCIENCES, 2022. DOI 10.3389/FMOLB.2022.831758

Low expression of PGC-1? and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1 CANCER LETTERS, 2022. DOI 10.1016/J.CANLET.2022.215738

Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency COMMUNICATIONS BIOLOGY, 2022. DOI 10.1038/S42003-022-03942-4

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation NAR CANCER, 2022. DOI 10.1093/NARCAN/ZCAC034

FACS-Free isolation and purification protocol of mouse prostate epithelial cells for organoid primary culture METHODSX, 2022. DOI 10.1016/J.MEX.2022.101843

Fatty acid oxidation enzyme Δ3, Δ2-enoyl-CoA isomerase 1 (ECI1) drives aggressive tumor phenotype and predicts poor clinical outcome in prostate cancer patients ONCOGENE, 2022. DOI 10.1038/S41388-022-02276-Z

Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion MOLECULAR METABOLISM, 2022. DOI 10.1016/J.MOLMET.2022.101516

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways. Scientific reports, 2021. Paquette M, Yan M, Ramírez-Reyes JMJ, El-Houjeiri L, Biondini M, Dufour CR, Jeong H, Pacis A, Giguère V, Estall JL, Siegel PM, Audet-Walsh É, Pause A.

Impacts of endocrine-disrupting chemicals on prostate function and cancer. Environmental research, 2021. Lacouture A, Lafront C, Peillex C, Pelletier M, Audet-Walsh É.

A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells. Frontiers in endocrinology, 2021. Lacouture A, Jobin C, Weidmann C, Berthiaume L, Bastien D, Laverdière I, Pelletier M, Audet-Walsh É.

KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism. Endocrine-related cancer, 2021. Poluri RTK, Paquette V, Allain ÉP, Lafront C, Joly-Beauparlant C, Weidmann C, Droit A, Guillemette C, Pelletier M, Audet-Walsh É.

A FACS-Free Purification Method to Study Estrogen Signaling, Organoid Formation, and Metabolic Reprogramming in Mammary Epithelial Cells FRONTIERS IN ENDOCRINOLOGY, 2021. DOI 10.3389/FENDO.2021.672466

Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021. DOI 10.3389/FCELL.2020.641552

Loss of hepatic <i>Flcn</i> protects against fibrosis and inflammation by activating autophagy pathways SCIENTIFIC REPORTS, 2021. DOI 10.1038/S41598-021-99958-7

KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism ENDOCRINE-RELATED CANCER, 2021. DOI 10.1530/ERC-20-0504